OVER-ALL RESPONSE OF INDUCTION CHEMOTHERAPY IN PATIENTS OF LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE ORAL CAVITY, OROPHARYNX, AND LARYNX AT ONCOLOGY DEPARTMENT JINNAH HOSPITAL, LAHORE
DOI:
https://doi.org/10.18623/rvd.v23.5978Palavras-chave:
Induction Chemotherapy, Locally Advanced Squamous Cell Carcinoma, Head And Neck Cancer, Oral Cavity Carcinoma, Oropharyngeal Carcinoma, Laryngeal Carcinoma, Carboplatin And Paclitaxel, Overall Response RateResumo
Background: Oral cavity, oropharynx, and larynx locally advanced squamous cell carcinoma (SCC) poses a great therapeutic challenge because of heavy tumor burden and functional impairment. Induction chemotherapy (IC) is becoming an increasingly popular way of downstaging tumors and enhancing the treatment. The purpose of this research was to assess the response to the induction chemotherapy in general in the patients of the Jinnah Hospital, Lahore, with locally advanced SCC. Objective: To identify the Over-all response of induction chemotherapy in patients with locally advanced squamous cell carcinoma of the oral cavity, Oropharynx and larynx in Jinnah Hospital, Lahore. Methods: This case series was a descriptive case series done in Oncology Department of Jinnah Hospital, Lahore from November 2025 to February 2026. Non-probability consecutive sampling was used to enroll 87 chemotherapy-naïve patients aged 1870 years with Stage III-IV SCC and ECOG performance status of 0-2. The patients were treated with induction chemotherapy consisting of carboplatin (AUC 3) and paclitaxel (125mg/m 2) after every two weeks during three cycles. At the 13th week, the response of tumors was evaluated through contrast-enhanced CT scans based on the criteria of RECIST 1.1. ORR was determined as the percentage of patients who had a complete response (CR) or partial response (PR). Results: Tumor responses were categorized as CR, PR, stable disease (SD), and progressive disease (PD). The overall response rate (CR + PR) was analyzed along with stratification for age, gender, tumor site, stage, and ECOG status. Statistical analysis was performed using SPSS version 26, and associations were assessed using the Chi-square test. Conclusion: Induction chemotherapy is shown to have a high overall response rate in patients with locally advanced SCC of the oral cavity, oropharynx and larynx, and therefore induction chemotherapy is an effective neoadjuvant treatment modality in clinical practice.
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