ACID BASE DISORDERS IN CHRONIC LIVER DISEASE CHILD CLASS B AND C ITS CORELATION WITH IN-HOSPITAL MORTALITY
DOI:
https://doi.org/10.18623/rvd.v23.5951Palavras-chave:
Chronic Liver Disease, Liver Cirrhosis, Acid-Base Imbalance, Metabolic Acidosis, Respiratory AlkalosisResumo
Background: Chronic liver disease (CLD) is a significant health burden in the world with high morbidity and mortality. The acid-base disorders (ABDs) are common in patients with a high liver disease and can lead to adverse clinical results. There is however limited information on their prevalence and prognostic effect in developing nations such as Pakistan. Objective: To identify the rate of acid-base disorders in chronic liver disease patients and to examine how these disorders relate to in-hospital mortality. Methodology: The study will be a descriptive study that will be carried out in the Department of General Medicine of the Fauji foundation hospital, Rawalpindi from October 2025 to January 2026. A sample size of 100 patients aged between 18 to 65 years with diagnosed CLD (Child-Pugh Class B and C) will be sampled through non-probability consecutive sampling. Arterial blood gas (ABG) will be used to determine acid-base status. The patients will be monitored within a period of 28 days to determine mortality. The analysis of data will be done under SPSS version 25. Results: It is believed that acid-base disorders especially the metabolic acidosis and respiratory alkalosis will be very common and greatly linked to high mortality. Summary: There is the possibility of early detection and treatment of acid-base disorders in CLD patients, which will positively affect the clinical outcomes and decrease mortality.
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