FREQUENCY OF GBS (GUILLAIN BARRE SYNDROME) WITH POST-COVID AND LONG COVID DISEASE IN CHILDREN ADMITTED IN CHILDREN HOSPITAL LAHORE

Autores/as

  • Tahseen Fatima University of Child Health Science and The Children's Hospital
  • Syed Muhammad Javed Iqbal University of Child Health Science and The Children's Hospital
  • imen Rasheed Children Hospital
  • Muhammad Usman University of Child Health Science and The Children's Hospital
  • Ramsha Bhatti University of Child Health Science and The Children's Hospital
  • Rida Batool WMO in THQ Chichawatni

DOI:

https://doi.org/10.18623/rvd.v23.5974

Palabras clave:

COVID-19, Post-COVID Syndrome, Long COVID, Guillain–Barré Syndrome (GBS), Peripheral Neuropathy, Acute Flaccid Paralysis (AFP), Immune-Mediated Neuropathy

Resumen

Background: A very broad range of neurological complications has been linked to coronavirus disease 2019 (COVID-19). Guillain-Barré Syndrome (GBS) is an autoimmune neuropathy which is on the rise after COVID-19 infection. Nonetheless, there is few data on its occurrence in children, especially in post-COVID and long COVID. Objective: To find the prevalence of post-COVID and long COVID disease in children hospitalized with GBS in The Children’s Hospital Lahore (CHL). Methodology: The study was a descriptive cross-sectional study performed in the Department of Neurology, CHL, from October 2025 to Jan 2026. Eighty-seven cases of GBS in children of 2-18 years were included using consecutive sampling. The exposure to COVID-19 was proven by antibody testing (IgM/IgG). The patients were identified with post-COVID (212 weeks) and long COVID (>12 weeks). The SPSS version 26.0 was used to analyze data. Results: In the case of 87 children with GBS, a major percentage of participants had previous exposure to COVID-19. The number of cases post-COVID was higher than the cases of long COVID. It was found that there was a statistically significant difference in age groups and post-COVID GBS (p ≤ 0.05) but no significant difference in gender. Conclusion: Pediatric populations are characterized by post-COVID neurological complications, especially the GBS. Childhood GBS should be diagnosed and treated promptly, and this is only possible through early detection and surveillance of COVID-19 patients.

Citas

Siracusa, L., Cascio, A., Giordano, S. et al. Neurological complications in pediatric patients with SARS-CoV-2 infection: a systematic review of the literature. Ital J Pediatr 2021;47, 123.

Mussinatto I, Benevenuta C, Caci A, Calvo MM, Impastato M, Barra M, Genovese E, Timeus F. Possible association between Guillain-Barré syndrome and SARS-CoV-2 infection in children: a case report and literature review. Exp Ther Med 2022; 23;24(1):462.

Pimentel V, Luchsinger VW, Carvalho GL, et al. Guillain-Barré syndrome associated with COVID-19: a systematic review. Brain Behav Immun Health. 2023;28:100578.

Shang P, Zhu M, Wang Y, Zheng X, Wu X, Zhu J, Feng J, Zhang HL. Axonal variants of Guillain-Barré syndrome: an update. J Neurol. 2021;268(7):2402-2419.

Aljomah L., Almedlej S., Baarmah D., Altwaijri W., Alrumayyan A., Alrifai M., et al. Pediatrics COVID-19 and neurological manifestations: single tertiary centre experience. eNeurol Sci 2021;24:100355.

Sánchez-Morales A., Urrutia-Osorio M., Camacho-Mendoza E., Rosales-Pedraza G., Dávila-Maldonado L., González-Duarte A., et al. Neurological manifestations temporally associated with SARS-CoV-2 infection in pediatric patients in Mexico. Childs Nerv Syst 2021;37:2305-12.

Barroso E, Tuta-Quintero E, Olivella J, Aragón C, Vásquez L, Acosta L, Pinzón O, et al. Síndrome de Guillain Barré en población pediátrica.¿ Consecuencia de la infección activa o de la covid prolongada?. Revist Colombiana Reumatol 2022;29(4):335-46.

Ray STJ, Abdel-Mannan O, Sa M, et al. Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study. Lancet Child Adolesc Health 2021;5(9):631-41.

Radišić V, Ždraljević M, Perić S, Mladenović B, Ralić B, Jovanović DR, et al. Is there a difference between GBS triggered by COVID-19 and those of other origins?. Egypt J Neurol Psychiatr Neurosurg 2022;58(1):54.

Toscano G, Palmerini F, Ravaglia S, et al. Guillain–Barré syndrome associated with SARS-CoV-2. N Engl J Med. 2020;382:2574–2576.

Keddie S, Pakpoor J, Mouseley C, et al. Epidemiological and clinical features of COVID-19 associated Guillain–Barré syndrome. Brain. 2021;144(12):3694–3702.

Say D, Crawford N, McNab S, et al. Post-acute COVID-19 outcomes in children and adolescents. Lancet Child Adolesc Health. 2021;5(12):863–872.

Willison HJ, Jacobs BC, van Doorn PA. Guillain–Barré syndrome. Lancet. 2016;388:717–727.

Paterson RW, Brown RL, Benjamin L, et al. The emerging spectrum of COVID-19 neurology. Brain. 2020;143(10):3104–3120.

Finsterer J, Scorza FA. Guillain–Barré syndrome in 220 patients with COVID-19. Egypt J Neurol Psychiatr Neurosurg. 2021;57:55.

Dalakas MC. Guillain–Barré syndrome: The first documented COVID-19-triggered autoimmune neurological disease. Nat Rev Neurol. 2020;16:443–445.

Abrams R, Walensky RP, Del Rio C, et al. COVID-19 and neurological complications. JAMA Neurol. 2020;77(10):1201–1202.

NINDS/NIH. Guillain–Barré Syndrome Information Page. National Institute of Neurological Disorders and Stroke, NIH. 2022.

CDC. Post-COVID conditions among children and adolescents. Centers for Disease Control and Prevention. 2023.

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Publicado

2026-03-08

Cómo citar

Fatima, T., Iqbal, S. M. J., Rasheed, imen, Usman, M., Bhatti, R., & Batool, R. (2026). FREQUENCY OF GBS (GUILLAIN BARRE SYNDROME) WITH POST-COVID AND LONG COVID DISEASE IN CHILDREN ADMITTED IN CHILDREN HOSPITAL LAHORE. Veredas Do Direito, 23(6), e235974. https://doi.org/10.18623/rvd.v23.5974