ASSOCIATION OF NON-ALCOHOLIC FATTY LIVER DISEASE WITH TYPE 2 DIABETES MELLITUS IN ADULT POPULATION
DOI:
https://doi.org/10.18623/rvd.v23.5971Palabras clave:
NAFLD, Type 2 Diabetes Mellitus, Fatty Liver Index, Pakistan, Metabolic SyndromeResumen
Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders worldwide and is strongly associated with metabolic conditions, particularly type 2 diabetes mellitus (T2DM). The coexistence of NAFLD and diabetes significantly increases the risk of liver-related morbidity and cardiovascular complications. Objective: To determine the association of NAFLD with type 2 diabetes mellitus in the adult population. Methodology: This case-control study was conducted in the Department of Medicine, Farooq Hospital / Akhtar Saeed Teaching Hospital, Lahore from October 2025 to January 2026. A total of 120 participants (60 cases with T2DM and 60 controls without diabetes) aged 30–70 years were enrolled using non-probability consecutive sampling. NAFLD was assessed using the Fatty Liver Index (FLI), calculated from triglycerides, BMI, γ-glutamyl transferase (GGT), and waist circumference. An FLI >30 was considered diagnostic of NAFLD. Data were analyzed using SPSS version 25. Odds ratio (OR) was calculated to assess the association. Results: The prevalence of NAFLD was significantly higher in diabetic patients compared to non-diabetics. The calculated odds ratio demonstrated a strong positive association (OR >1) between T2DM and NAFLD. Stratified analysis showed stronger associations in patients with higher BMI, uncontrolled HbA1c, and sedentary lifestyle. Conclusion: There is a significant association between NAFLD and type 2 diabetes mellitus. Early screening for NAFLD in diabetic patients is recommended to reduce disease progression and associated complications.
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