DEVELOPMENT OF A RAPID COLORIMETRIC PAPER-BASED TEST KIT FOR ON-SITE SCREENING OF PARABENS IN COSMETIC AND HEALTHCARE PRODUCTS
DOI:
https://doi.org/10.18623/rvd.v22.n4.3672Palabras clave:
Parabens, Colorimetric Detection, Paper-based Sensor, Ferric Chloride, Rapid ScreeningResumen
Os parabenos, uma classe de ésteres sintéticos do ácido p-hidroxibenzóico, são amplamente utilizados como conservantes em cosméticos, produtos farmacêuticos e de higiene pessoal, levantando preocupações crescentes sobre seus potenciais efeitos desreguladores endócrinos e riscos de exposição cumulativa. Este estudo teve como objetivo desenvolver um kit colorimétrico em papel, rápido, de baixo custo e fácil de usar, para a detecção in loco de parabenos. Dois sistemas cromogênicos — o acoplamento diazônio Fast Blue RR e a complexação com íons férricos (Fe³⁺) — foram comparados; o sistema FeCl₃ foi selecionado por apresentar maior intensidade e estabilidade de cor. As condições de reação foram otimizadas quanto à composição do solvente, razão reagente-analito, concentração e pH, apresentando melhor desempenho com 10% de FeCl₃ em etanol a 20%, pH 8,0 e razão 1:10. A fita otimizada produziu uma coloração roxa visível em 1 minuto, com limite de detecção de 0,2% e estabilidade da cor por aproximadamente 16 minutos. O kit demonstrou alta seletividade, com interferência mínima da matriz, e foi aplicado com sucesso em 25 amostras comerciais, detectando parabenos em 16% dos produtos, principalmente cosméticos. Embora menos sensível que métodos cromatográficos ou eletroquímicos avançados, a fita em papel baseada em FeCl₃ oferece uma ferramenta prática e rápida para triagem preliminar, controle de qualidade e vigilância em campo, especialmente em contextos com recursos limitados.
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